The effect of variant interference on de novo assembly for viral deep sequencing

BACKGROUND: Viruses have high mutation rates and generally exist as a mixture of variants in biological samples. Next-generation sequencing (NGS) approaches have surpassed Sanger for generating long viral sequences, yet how variants affect NGS de novo assembly remains largely unexplored. RESULTS: Ou...

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Detalles Bibliográficos
Autores principales: Castro, Christina J., Marine, Rachel L., Ramos, Edward, Ng, Terry Fei Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306937/
https://www.ncbi.nlm.nih.gov/pubmed/32571214
http://dx.doi.org/10.1186/s12864-020-06801-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306937/
https://www.ncbi.nlm.nih.gov/pubmed/32571214
http://dx.doi.org/10.1186/s12864-020-06801-w

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