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Depletion interactions modulate the binding between disordered proteins in crowded environments

Intrinsically disordered proteins (IDPs) abound in cellular regulation. Their interactions are often transitory and highly sensitive to salt concentration and posttranslational modifications. However, little is known about the effect of macromolecular crowding on the interactions of IDPs with their...

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Detalles Bibliográficos
Autores principales: Zosel, Franziska, Soranno, Andrea, Buholzer, Karin J., Nettels, Daniel, Schuler, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306994/
https://www.ncbi.nlm.nih.gov/pubmed/32487732
http://dx.doi.org/10.1073/pnas.1921617117