Impairment of the DeISGylation Activity of Foot-and-Mouth Disease Virus Lpro Causes Attenuation In Vitro and In Vivo

Foot-and-mouth disease virus (FMDV) leader proteinase (Lpro) affects several pathways of the host innate immune response. Previous studies in bovine cells demonstrated that deletions (leaderless [LLV]) or point mutations in Lpro result in increased expression of interferon (IFN) and IFN-stimulated g...

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Detalles Bibliográficos
Autores principales: Medina, Gisselle N., Azzinaro, Paul, Ramirez-Medina, Elizabeth, Gutkoska, Joseph, Fang, Ying, Diaz-San Segundo, Fayna, de los Santos, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307143/
https://www.ncbi.nlm.nih.gov/pubmed/32295921
http://dx.doi.org/10.1128/JVI.00341-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307143/
https://www.ncbi.nlm.nih.gov/pubmed/32295921
http://dx.doi.org/10.1128/JVI.00341-20

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