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IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival
In the tumor microenvironment, local immune dysregulation is driven in part by macrophages and dendritic cells that are polarized to a mixed proinflammatory/immune-suppressive phenotype. The unfolded protein response (UPR) is emerging as the possible origin of these events. Here we report that the i...
Autores principales: | Batista, Alyssa, Rodvold, Jeffrey J., Xian, Su, Searles, Stephen C., Lew, Alyssa, Iwawaki, Takao, Almanza, Gonzalo, Waller, T. Cameron, Lin, Jonathan, Jepsen, Kristen, Carter, Hannah, Zanetti, Maurizio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307794/ https://www.ncbi.nlm.nih.gov/pubmed/32520957 http://dx.doi.org/10.1371/journal.pbio.3000687 |
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