Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm

[Image: see text] We have previously shown that the thermolabile, cavity-creating p53 cancer mutant Y220C can be reactivated by small-molecule stabilizers. In our ongoing efforts to unearth druggable variants of the p53 mutome, we have now analyzed the effects of other cancer-associated mutations at...

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Detalles Bibliográficos
Autores principales: Bauer, Matthias R., Krämer, Andreas, Settanni, Giovanni, Jones, Rhiannon N., Ni, Xiaomin, Khan Tareque, Raysa, Fersht, Alan R., Spencer, John, Joerger, Andreas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307883/
https://www.ncbi.nlm.nih.gov/pubmed/31990523
http://dx.doi.org/10.1021/acschembio.9b00748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307883/
https://www.ncbi.nlm.nih.gov/pubmed/31990523
http://dx.doi.org/10.1021/acschembio.9b00748

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