Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design

[Image: see text] The knowledge on human serum albumin (HSA) binding is of utmost importance as it affects pharmacokinetic behavior and bioavailability of drugs. In this article, we report a novel method to screen for ionizable molecules with high HSA binding affinity based on pK(a) shifts using UV-...

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Detalles Bibliográficos
Autores principales: Dargó, Gergő, Bajusz, Dávid, Simon, Kristóf, Müller, Judit, Balogh, György T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307925/
https://www.ncbi.nlm.nih.gov/pubmed/31995375
http://dx.doi.org/10.1021/acs.jmedchem.0c00046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307925/
https://www.ncbi.nlm.nih.gov/pubmed/31995375
http://dx.doi.org/10.1021/acs.jmedchem.0c00046

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