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Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design
[Image: see text] The knowledge on human serum albumin (HSA) binding is of utmost importance as it affects pharmacokinetic behavior and bioavailability of drugs. In this article, we report a novel method to screen for ionizable molecules with high HSA binding affinity based on pK(a) shifts using UV-...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307925/ https://www.ncbi.nlm.nih.gov/pubmed/31995375 http://dx.doi.org/10.1021/acs.jmedchem.0c00046 |