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Adeno-associated virus-binding antibodies detected in cats living in the Northeastern United States lack neutralizing activity

Cats are a critical pre-clinical model for studying adeno-associated virus (AAV) vector-mediated gene therapies. A recent study has described the high prevalence of anti-AAV neutralizing antibodies among domestic cats in Switzerland. However, our knowledge of pre-existing humoral immunity against va...

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Detalles Bibliográficos
Autores principales:	Adachi, Kei, Dissen, Gregory A., Lomniczi, Alejandro, Xie, Qing, Ojeda, Sergio R., Nakai, Hiroyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308316/ https://www.ncbi.nlm.nih.gov/pubmed/32572045 http://dx.doi.org/10.1038/s41598-020-66596-4

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