Adeno-associated virus-binding antibodies detected in cats living in the Northeastern United States lack neutralizing activity

Cats are a critical pre-clinical model for studying adeno-associated virus (AAV) vector-mediated gene therapies. A recent study has described the high prevalence of anti-AAV neutralizing antibodies among domestic cats in Switzerland. However, our knowledge of pre-existing humoral immunity against va...

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Detalles Bibliográficos
Autores principales: Adachi, Kei, Dissen, Gregory A., Lomniczi, Alejandro, Xie, Qing, Ojeda, Sergio R., Nakai, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308316/
https://www.ncbi.nlm.nih.gov/pubmed/32572045
http://dx.doi.org/10.1038/s41598-020-66596-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308316/
https://www.ncbi.nlm.nih.gov/pubmed/32572045
http://dx.doi.org/10.1038/s41598-020-66596-4

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