Matriptase processing of APLP1 ectodomain alters its homodimerization

The amyloid beta peptide (Aβ) is derived from the amyloid precursor protein (APP) by secretase processing. APP is also cleaved by numerous other proteases, such as the type II transmembrane serine protease matriptase, with consequences on the production of Aβ. Because the APP homolog protein amyloid...

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Detalles Bibliográficos
Autores principales: Lanchec, Erwan, Désilets, Antoine, Béliveau, François, Fontaine-Carbonneau, Cloé, Laniel, Andréanne, Leduc, Richard, Lavoie, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308337/
https://www.ncbi.nlm.nih.gov/pubmed/32572095
http://dx.doi.org/10.1038/s41598-020-67005-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308337/
https://www.ncbi.nlm.nih.gov/pubmed/32572095
http://dx.doi.org/10.1038/s41598-020-67005-6

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