Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome

The eukaryotic leading strand DNA polymerase (Pol) ε contains 4 subunits, Pol2, Dpb2, Dpb3 and Dpb4. Pol2 is a fusion of two B-family Pols; the N-terminal Pol module is catalytic and the C-terminal Pol module is non-catalytic. Despite extensive efforts, there is no atomic structure for Pol ε holoenz...

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Detalles Bibliográficos
Autores principales: Yuan, Zuanning, Georgescu, Roxana, Schauer, Grant D., O’Donnell, Michael E., Li, Huilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308368/
https://www.ncbi.nlm.nih.gov/pubmed/32572031
http://dx.doi.org/10.1038/s41467-020-16910-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308368/
https://www.ncbi.nlm.nih.gov/pubmed/32572031
http://dx.doi.org/10.1038/s41467-020-16910-5

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