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Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation
The PIDDosome is a multiprotein complex that drives activation of caspase-2, an endopeptidase originally implicated in apoptosis. Yet, unlike other caspases involved in cell death and inflammation, caspase-2 seems to exert additional versatile functions unrelated to cell death. These emerging roles...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308375/ https://www.ncbi.nlm.nih.gov/pubmed/32415279 http://dx.doi.org/10.1038/s41418-020-0556-6 |
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author | Sladky, Valentina C. Villunger, Andreas |
author_facet | Sladky, Valentina C. Villunger, Andreas |
author_sort | Sladky, Valentina C. |
collection | PubMed |
description | The PIDDosome is a multiprotein complex that drives activation of caspase-2, an endopeptidase originally implicated in apoptosis. Yet, unlike other caspases involved in cell death and inflammation, caspase-2 seems to exert additional versatile functions unrelated to cell death. These emerging roles range from control of transcription factor activity to ploidy surveillance. Thus, caspase-2 and the PIDDosome act as a critical regulatory unit controlling cellular differentiation processes during organogenesis and regeneration. These newly established functions of the PIDDosome and its downstream effector render its components attractive targets for drug-development aiming to prevent fatty liver diseases, neurodegenerative disorders or osteoporosis. |
format | Online Article Text |
id | pubmed-7308375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73083752020-06-23 Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation Sladky, Valentina C. Villunger, Andreas Cell Death Differ Review Article The PIDDosome is a multiprotein complex that drives activation of caspase-2, an endopeptidase originally implicated in apoptosis. Yet, unlike other caspases involved in cell death and inflammation, caspase-2 seems to exert additional versatile functions unrelated to cell death. These emerging roles range from control of transcription factor activity to ploidy surveillance. Thus, caspase-2 and the PIDDosome act as a critical regulatory unit controlling cellular differentiation processes during organogenesis and regeneration. These newly established functions of the PIDDosome and its downstream effector render its components attractive targets for drug-development aiming to prevent fatty liver diseases, neurodegenerative disorders or osteoporosis. Nature Publishing Group UK 2020-05-15 2020-07 /pmc/articles/PMC7308375/ /pubmed/32415279 http://dx.doi.org/10.1038/s41418-020-0556-6 Text en © The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Sladky, Valentina C. Villunger, Andreas Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation |
title | Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation |
title_full | Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation |
title_fullStr | Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation |
title_full_unstemmed | Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation |
title_short | Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation |
title_sort | uncovering the piddosome and caspase-2 as regulators of organogenesis and cellular differentiation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308375/ https://www.ncbi.nlm.nih.gov/pubmed/32415279 http://dx.doi.org/10.1038/s41418-020-0556-6 |
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