AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma

Cutaneous malignant melanoma (CMM) is the deadliest form of skin cancer and clinically challenging due to its propensity to develop therapy resistance. Reactive oxygen species (ROS) can induce DNA damage and play a significant role in CMM. MTH1 protein protects from ROS damage and is often overexpre...

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Detalles Bibliográficos
Autores principales: Das, Ishani, Gad, Helge, Bräutigam, Lars, Pudelko, Linda, Tuominen, Rainer, Höiom, Veronica, Almlöf, Ingrid, Rajagopal, Varshni, Hansson, Johan, Helleday, Thomas, Egyházi Brage, Suzanne, Warpman Berglund, Ulrika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308409/
https://www.ncbi.nlm.nih.gov/pubmed/31919461
http://dx.doi.org/10.1038/s41418-019-0488-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308409/
https://www.ncbi.nlm.nih.gov/pubmed/31919461
http://dx.doi.org/10.1038/s41418-019-0488-1

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