Akt Inhibition Is Associated With Favorable Immune Profile Changes Within the Tumor Microenvironment of Hormone Receptor Positive, HER2 Negative Breast Cancer

Background: The PI3K/Akt/mTOR pathway in part impacts tumorigenesis through modulation of host immune activity. To assess the effects of Akt inhibition on the tumor micro-environment (TME), we analyzed tumor tissue from patients with operable hormone receptor positive, HER2 negative breast cancer (B...

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Detalles Bibliográficos
Autores principales: Marks, Douglas K., Gartrell, Robyn D., El Asmar, Margueritta, Boboila, Shuobo, Hart, Thomas, Lu, Yan, Pan, Qingfei, Yu, Jiyang, Hibshoosh, Hanina, Guo, Hua, Andreopoulou, Eleni, Wiechmann, Lisa, Crew, Katherine, Sparano, Joseph, Hershman, Dawn, Connolly, Eileen, Saenger, Yvonne, Kalinsky, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308467/
https://www.ncbi.nlm.nih.gov/pubmed/32612958
http://dx.doi.org/10.3389/fonc.2020.00968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308467/
https://www.ncbi.nlm.nih.gov/pubmed/32612958
http://dx.doi.org/10.3389/fonc.2020.00968

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