Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus

MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered therapeutic chimeric antigen receptor (CAR) T cells in their speci...

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Detalles Bibliográficos
Autores principales: Van Laethem, François, Saba, Ingrid, Lu, Jinghua, Bhattacharya, Abhisek, Tai, Xuguang, Guinter, Terry I., Engelhardt, Britta, Alag, Amala, Rojano, Mirelle, Ashe, Jennifer M., Hanada, Ken-ichi, Yang, James C., Sun, Peter D., Singer, Alfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308553/
https://www.ncbi.nlm.nih.gov/pubmed/32612609
http://dx.doi.org/10.3389/fimmu.2020.01216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308553/
https://www.ncbi.nlm.nih.gov/pubmed/32612609
http://dx.doi.org/10.3389/fimmu.2020.01216

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