NOTCH inhibition promotes bronchial stem cell renewal and epithelial barrier integrity after irradiation

Hyperactivity of the NOTCH pathway is associated with tumor growth and radiotherapy resistance in lung cancer, and NOTCH/γ‐secretase inhibitors (GSIs) are a potential therapeutic target. The therapeutic outcome, however, is often restricted by the dose‐limiting toxicity of combined treatments on the...

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Detalles Bibliográficos
Autores principales: Giuranno, Lorena, Roig, Eloy M., Wansleeben, Carolien, van den Berg, Annette, Groot, Arjan J., Dubois, Ludwig, Vooijs, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Tissue‐specific Progenitor and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308641/
https://www.ncbi.nlm.nih.gov/pubmed/32297712
http://dx.doi.org/10.1002/sctm.19-0278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308641/
https://www.ncbi.nlm.nih.gov/pubmed/32297712
http://dx.doi.org/10.1002/sctm.19-0278

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