Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4

[Image: see text] Targeting protein degradation with Proteolysis-Targeting Chimeras (PROTACs) is an area of great current interest in drug discovery. Nevertheless, although the high effectiveness of PROTACs against a wide variety of targets has been established, most degraders reported to date displ...

Descripción completa

Detalles Bibliográficos
Autores principales: Maneiro, María, Forte, Nafsika, Shchepinova, Maria M., Kounde, Cyrille S., Chudasama, Vijay, Baker, James Richard, Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309268/
https://www.ncbi.nlm.nih.gov/pubmed/32338867
http://dx.doi.org/10.1021/acschembio.0c00285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309268/
https://www.ncbi.nlm.nih.gov/pubmed/32338867
http://dx.doi.org/10.1021/acschembio.0c00285

Ejemplares similares