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Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4
[Image: see text] Targeting protein degradation with Proteolysis-Targeting Chimeras (PROTACs) is an area of great current interest in drug discovery. Nevertheless, although the high effectiveness of PROTACs against a wide variety of targets has been established, most degraders reported to date displ...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309268/ https://www.ncbi.nlm.nih.gov/pubmed/32338867 http://dx.doi.org/10.1021/acschembio.0c00285 |