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High-Throughput Screening for Substrate Specificity-Adapted Mutants of the Nisin Dehydratase NisB
[Image: see text] Microbial lanthipeptides are formed by a two-step enzymatic introduction of (methyl)lanthionine rings. A dehydratase catalyzes the dehydration of serine and threonine residues, yielding dehydroalanine and dehydrobutyrine, respectively. Cyclase-catalyzed coupling of the formed dehyd...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309312/ https://www.ncbi.nlm.nih.gov/pubmed/32374981 http://dx.doi.org/10.1021/acssynbio.0c00130 |