Conformationally Locked Pyramidality Explains the Diastereoselectivity in the Methylation of trans-Fused Butyrolactones

[Image: see text] A stereoselectivity model inspired by the total synthesis of stemona alkaloids is developed to explain why enolate-derived 3,4-fused butyrolactones are methylated with a preference for syn alkylation. The model shows how conformational locking present in nonplanar enolate structure...

Descripción completa

Detalles Bibliográficos
Autores principales: Csókás, Dániel, Siitonen, Juha H., Pihko, Petri M., Pápai, Imre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309317/
https://www.ncbi.nlm.nih.gov/pubmed/32338517
http://dx.doi.org/10.1021/acs.orglett.0c01008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309317/
https://www.ncbi.nlm.nih.gov/pubmed/32338517
http://dx.doi.org/10.1021/acs.orglett.0c01008

Ejemplares similares