Arrayed CRISPR Screening Identifies Novel Targets That Enhance the Productive Delivery of mRNA by MC3-Based Lipid Nanoparticles

Modified messenger RNAs (mRNAs) hold great potential as therapeutics by using the body’s own processes for protein production. However, a key challenge is efficient delivery of therapeutic mRNA to the cell cytosol and productive protein translation. Lipid nanoparticles (LNPs) are the most clinically...

Descripción completa

Detalles Bibliográficos
Autores principales: Ross-Thriepland, Douglas, Bornot, Aurelie, Butler, Larissa, Desai, Arpan, Jaiswal, Himjyot, Peel, Samantha, Hunter, Morag Rose, Odunze, Uchechukwu, Isherwood, Beverley, Gianni, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309353/
https://www.ncbi.nlm.nih.gov/pubmed/32441189
http://dx.doi.org/10.1177/2472555220925770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309353/
https://www.ncbi.nlm.nih.gov/pubmed/32441189
http://dx.doi.org/10.1177/2472555220925770

Ejemplares similares