Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies

Tau protein abnormally aggregates in tauopathies, a diverse group of neurologic diseases that includes Alzheimer’s disease (AD). In early stages of disease, tau becomes hyperphosphorylated and mislocalized, which can contribute to its aggregation and toxicity. We demonstrate that tau phosphorylation...

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Detalles Bibliográficos
Autores principales: Xia, Yuxing, Prokop, Stefan, Gorion, Kimberly-Marie M., Kim, Justin D., Sorrentino, Zachary A., Bell, Brach M., Manaois, Alyssa N., Chakrabarty, Paramita, Davies, Peter, Giasson, Benoit I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310041/
https://www.ncbi.nlm.nih.gov/pubmed/32571418
http://dx.doi.org/10.1186/s40478-020-00967-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310041/
https://www.ncbi.nlm.nih.gov/pubmed/32571418
http://dx.doi.org/10.1186/s40478-020-00967-w

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