Tumor suppressor OTUD3 induces growth inhibition and apoptosis by directly deubiquitinating and stabilizing p53 in invasive breast carcinoma cells

BACKGROUND: P53 pathway inactivation plays an important role in the process of breast cancer tumorigenesis. Post-translational protein modification abnormalities have been confirmed to be an important mechanism underlying inactivation of p53. Numerous deubiquitinating enzymes are aberrantly expresse...

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Detalles Bibliográficos
Autores principales: Pu, Qian, Lv, Yan-rong, Dong, Ke, Geng, Wen-wen, Gao, Hai-dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310228/
https://www.ncbi.nlm.nih.gov/pubmed/32571254
http://dx.doi.org/10.1186/s12885-020-07069-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310228/
https://www.ncbi.nlm.nih.gov/pubmed/32571254
http://dx.doi.org/10.1186/s12885-020-07069-9

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