Dysregulation of FOXO1 (Forkhead Box O1 Protein) Drives Calcification in Arterial Calcification due to Deficiency of CD73 and Is Present in Peripheral Artery Disease

OBJECTIVE: The recessive disease arterial calcification due to deficiency of CD73 (ACDC) presents with extensive nonatherosclerotic medial layer calcification in lower extremity arteries. Lack of CD73 induces a concomitant increase in TNAP (tissue nonspecific alkaline phosphatase; ALPL), a key enzym...

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Detalles Bibliográficos
Autores principales: Moorhead, William J., Chu, Claire C., Cuevas, Rolando A., Callahan, Jack, Wong, Ryan, Regan, Cailyn, Boufford, Camille K., Sur, Swastika, Liu, Mingjun, Gomez, Delphine, MacTaggart, Jason N., Kamenskiy, Alexey, Boehm, Manfred, St. Hilaire, Cynthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Basic Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310306/
https://www.ncbi.nlm.nih.gov/pubmed/32375544
http://dx.doi.org/10.1161/ATVBAHA.119.313765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310306/
https://www.ncbi.nlm.nih.gov/pubmed/32375544
http://dx.doi.org/10.1161/ATVBAHA.119.313765

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