Impacts of drug resistance mutations on the structural asymmetry of the HIV-2 protease

BACKGROUND: Drug resistance is a severe problem in HIV treatment. HIV protease is a common target for the design of new drugs for treating HIV infection. Previous studies have shown that the crystallographic structures of the HIV-2 protease (PR2) in bound and unbound forms exhibit structural asymmet...

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Detalles Bibliográficos
Autores principales: Laville, Pierre, Fartek, Sandrine, Cerisier, Natacha, Flatters, Delphine, Petitjean, Michel, Regad, Leslie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310402/
https://www.ncbi.nlm.nih.gov/pubmed/32576133
http://dx.doi.org/10.1186/s12860-020-00290-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310402/
https://www.ncbi.nlm.nih.gov/pubmed/32576133
http://dx.doi.org/10.1186/s12860-020-00290-1

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