Cargando…

Impacts of drug resistance mutations on the structural asymmetry of the HIV-2 protease

BACKGROUND: Drug resistance is a severe problem in HIV treatment. HIV protease is a common target for the design of new drugs for treating HIV infection. Previous studies have shown that the crystallographic structures of the HIV-2 protease (PR2) in bound and unbound forms exhibit structural asymmet...

Descripción completa

Detalles Bibliográficos
Autores principales:	Laville, Pierre, Fartek, Sandrine, Cerisier, Natacha, Flatters, Delphine, Petitjean, Michel, Regad, Leslie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310402/ https://www.ncbi.nlm.nih.gov/pubmed/32576133 http://dx.doi.org/10.1186/s12860-020-00290-1

Ejemplares similares

Structural Impacts of Drug-Resistance Mutations Appearing in HIV-2 Protease
por: Laville, Pierre, et al.
Publicado: (2021)

Analysis of the HIV-2 protease’s adaptation to various ligands: characterization of backbone asymmetry using a structural alphabet
por: Triki, Dhoha, et al.
Publicado: (2018)

Cavity Versus Ligand Shape Descriptors: Application to Urokinase Binding Pockets
por: Cerisier, Natacha, et al.
Publicado: (2017)

High Impact: The Role of Promiscuous Binding Sites in Polypharmacology
por: Cerisier, Natacha, et al.
Publicado: (2019)

Exploration of the effect of sequence variations located inside the binding pocket of HIV-1 and HIV-2 proteases
por: Triki, Dhoha, et al.
Publicado: (2018)

SAFlex: A structural alphabet extension to integrate protein structural flexibility and missing data information
por: Allam, Ikram, et al.
Publicado: (2018)

Exploring the potential of a structural alphabet-based tool for mining multiple target conformations and target flexibility insight
por: Regad, Leslie, et al.
Publicado: (2017)

Drug‐target‐ADR Network and Possible Implications of Structural Variants in Adverse Events
por: Dafniet, Bryan, et al.
Publicado: (2020)

PockDrug-Server: a new web server for predicting pocket druggability on holo and apo proteins
por: Hussein, Hiba Abi, et al.
Publicado: (2015)

Structural analyses of 2015-updated drug-resistant mutations in HIV-1 protease: an implication of protease inhibitor cross-resistance
por: Su, Chinh Tran-To, et al.
Publicado: (2016)

Assessment of Drug-Induced Liver Injury through Cell Morphology and Gene Expression Analysis
por: Lejal, Vanille, et al.
Publicado: (2023)

Synthetic lethals in HIV: ways to avoid drug resistance: Running title: Preventing HIV resistance
por: Petitjean, Michel, et al.
Publicado: (2015)

Analysis of drug resistance in HIV protease
por: Pawar, Shrikant D., et al.
Publicado: (2018)

Evolution of drug resistance in HIV protease
por: Shah, Dhara, et al.
Publicado: (2020)

HIV-1 Protease: Structural Perspectives on Drug Resistance
por: Weber, Irene T., et al.
Publicado: (2009)

Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease
por: Cai, Yufeng, et al.
Publicado: (2014)

Prevalence of drug resistance mutations in HIV-1 protease gene from North India
por: Azam, Mohd, et al.
Publicado: (2012)

Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease
por: Zhang, Tian-hao, et al.
Publicado: (2020)

Evaluation of novel Saquinavir analogs for resistance mutation compatibility and potential as an HIV-Protease inhibitor drug
por: Jayaswal, Amit, et al.
Publicado: (2014)

Effects of drug-resistant mutations on the dynamic properties of HIV-1 protease and inhibition by Amprenavir and Darunavir
por: Yu, Yuqi, et al.
Publicado: (2015)

Evolving Mutational Buildup in HIV-1 Protease Shifts Conformational Dynamics to Gain Drug Resistance
por: Souffrant, Michael, et al.
Publicado: (2023)

Comprehending the Structure, Dynamics, and Mechanism of Action of Drug-Resistant HIV Protease
por: Dakshinamoorthy, Avinash, et al.
Publicado: (2023)

Molecular Basis for Drug Resistance in HIV-1 Protease
por: Ali, Akbar, et al.
Publicado: (2010)

Dynamical Basis for Drug Resistance of HIV-1 Protease
por: Mao, Yi
Publicado: (2011)

HIV-1 Protease as DNA Immunogen against Drug Resistance in HIV-1 Infection: DNA Immunization with Drug Resistant HIV-1 Protease Protects Mice from Challenge with Protease-Expressing Cells
por: Petkov, Stefan, et al.
Publicado: (2022)

Collinearity of protease mutations in HIV-1 samples with high-level protease inhibitor class resistance
por: Babrzadeh, Farbod, et al.
Publicado: (2013)

Drug Resistance Conferred by Mutations Outside the Active Site through Alterations in the Dynamic and Structural Ensemble of HIV-1 Protease
por: Ragland, Debra A., et al.
Publicado: (2014)

Pairwise and higher-order correlations among drug-resistance mutations in HIV-1 subtype B protease
por: Haq, Omar, et al.
Publicado: (2009)

Protease and gag diversity and drug resistance mutations among treatment-naive Mexican people living with HIV
por: Climaco-Arvizu, Samantha, et al.
Publicado: (2022)

HIV-1 reverse transcriptase and protease mutations for drug-resistance detection among treatment-experienced and naïve HIV-infected individuals
por: Bokharaei-Salim, Farah, et al.
Publicado: (2020)

Drug Resistance Mutations Against Protease, Reverse Transcriptase and Integrase Inhibitors in People Living With HIV-1 Receiving Boosted Protease Inhibitors in South Africa
por: Obasa, Adetayo Emmanuel, et al.
Publicado: (2020)

Detection and Architecture of Small Heat Shock Protein Monomers
por: Poulain, Pierre, et al.
Publicado: (2010)

Sequence and structure based models of HIV-1 protease and reverse transcriptase drug resistance
por: Masso, Majid, et al.
Publicado: (2013)

Deep Sequencing of Protease Inhibitor Resistant HIV Patient Isolates Reveals Patterns of Correlated Mutations in Gag and Protease
por: Flynn, William F., et al.
Publicado: (2015)

An Allosteric Modulator of HIV-1 Protease Shows Equipotent Inhibition of Wild-Type and Drug-Resistant Proteases
por: Ung, Peter M.-U., et al.
Publicado: (2014)

Resistance associated mutations to protease inhibitors on HIV-2 infected patients in Portugal
por: Lopes, J., et al.
Publicado: (2021)

Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap–Core Interface of HIV-1 Protease
por: Wong-Sam, Andres, et al.
Publicado: (2018)

Reverse transcriptase and protease inhibitors mutational viral load in HIV infected pregnant women with transmitted drug resistance in Argentina
por: Cecchini, Diego, et al.
Publicado: (2021)

Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics
por: Agniswamy, Johnson, et al.
Publicado: (2016)

HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat
por: Fun, Axel, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_2t0b8f4nf33g1r2967ap1k9o1c