The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity

SARS coronavirus 2 (SARS-CoV-2) isolates encoding a D614G mutation in the viral spike (S) protein predominate over time in locales where it is found, implying that this change enhances viral transmission. We therefore compared the functional properties of the S proteins with aspartic acid (S(D614))...

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Detalles Bibliográficos
Autores principales: Zhang, Lizhou, Jackson, Cody B, Mou, Huihui, Ojha, Amrita, Rangarajan, Erumbi S, Izard, Tina, Farzan, Michael, Choe, Hyeryun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310631/
https://www.ncbi.nlm.nih.gov/pubmed/32587973
http://dx.doi.org/10.1101/2020.06.12.148726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310631/
https://www.ncbi.nlm.nih.gov/pubmed/32587973
http://dx.doi.org/10.1101/2020.06.12.148726

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