Zebrafish rbm8a and magoh mutants reveal EJC developmental functions and new 3′UTR intron-containing NMD targets

Many post-transcriptional mechanisms operate via mRNA 3′UTRs to regulate protein expression, and such controls are crucial for development. We show that homozygous mutations in two zebrafish exon junction complex (EJC) core genes rbm8a and magoh leads to muscle disorganization, neural cell death, an...

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Detalles Bibliográficos
Autores principales: Gangras, Pooja, Gallagher, Thomas L., Parthun, Michael A., Yi, Zhongxia, Patton, Robert D., Tietz, Kiel T., Deans, Natalie C., Bundschuh, Ralf, Amacher, Sharon L., Singh, Guramrit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310861/
https://www.ncbi.nlm.nih.gov/pubmed/32502192
http://dx.doi.org/10.1371/journal.pgen.1008830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310861/
https://www.ncbi.nlm.nih.gov/pubmed/32502192
http://dx.doi.org/10.1371/journal.pgen.1008830

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