α-ketobutyrate links alterations in cystine metabolism to glucose oxidation in mtDNA mutant cells

Pathogenic mutations in the mitochondrial genome (mtDNA) impair organellar ATP production, requiring mutant cells to activate metabolic adaptations for survival. Understanding how metabolism adapts to clinically relevant mtDNA mutations may provide insight into cellular strategies for metabolic flex...

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Detalles Bibliográficos
Autores principales: Lesner, Nicholas P., Gokhale, Amrita S., Kota, Kalyani, DeBerardinis, Ralph J., Mishra, Prashant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310915/
https://www.ncbi.nlm.nih.gov/pubmed/32330654
http://dx.doi.org/10.1016/j.ymben.2020.03.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310915/
https://www.ncbi.nlm.nih.gov/pubmed/32330654
http://dx.doi.org/10.1016/j.ymben.2020.03.010

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