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α-ketobutyrate links alterations in cystine metabolism to glucose oxidation in mtDNA mutant cells
Pathogenic mutations in the mitochondrial genome (mtDNA) impair organellar ATP production, requiring mutant cells to activate metabolic adaptations for survival. Understanding how metabolism adapts to clinically relevant mtDNA mutations may provide insight into cellular strategies for metabolic flex...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310915/ https://www.ncbi.nlm.nih.gov/pubmed/32330654 http://dx.doi.org/10.1016/j.ymben.2020.03.010 |