Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes

Dynamic trafficking of G protein-coupled receptors (GPCRs) out of cilia is mediated by the BBSome. In concert with its membrane recruitment factor, the small GTPase ARL6/BBS3, the BBSome ferries GPCRs across the transition zone, a diffusion barrier at the base of cilia. Here, we present the near-ato...

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Detalles Bibliográficos
Autores principales: Yang, Shuang, Bahl, Kriti, Chou, Hui-Ting, Woodsmith, Jonathan, Stelzl, Ulrich, Walz, Thomas, Nachury, Maxence V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311171/
https://www.ncbi.nlm.nih.gov/pubmed/32510327
http://dx.doi.org/10.7554/eLife.55954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311171/
https://www.ncbi.nlm.nih.gov/pubmed/32510327
http://dx.doi.org/10.7554/eLife.55954

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