Direct Antiviral Activity of IFN-Stimulated Genes Is Responsible for Resistance to Paramyxoviruses in ISG15-Deficient Cells

IFNs, produced during viral infections, induce the expression of hundreds of IFN-stimulated genes (ISGs). Some ISGs have specific antiviral activity, whereas others regulate the cellular response. Besides functioning as an antiviral effector, ISG15 is a negative regulator of IFN signaling, and inher...

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Detalles Bibliográficos
Autores principales: Holthaus, David, Vasou, Andri, Bamford, Connor G. G., Andrejeva, Jelena, Paulus, Christina, Randall, Richard E., McLauchlan, John, Hughes, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2020
Materias:
Innate Immunity and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311202/
https://www.ncbi.nlm.nih.gov/pubmed/32423918
http://dx.doi.org/10.4049/jimmunol.1901472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311202/
https://www.ncbi.nlm.nih.gov/pubmed/32423918
http://dx.doi.org/10.4049/jimmunol.1901472

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