A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway

Glucose is catabolized by two fundamental pathways, glycolysis to make ATP and the oxidative pentose phosphate pathway to make NADPH. The first step of the oxidative pentose phosphate pathway is catalyzed by the enzyme glucose-6-phosphate dehydrogenase (G6PD). Here we develop metabolite reporter and...

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Detalles Bibliográficos
Autores principales: Ghergurovich, Jonathan M., García-Cañaveras, Juan C., Wang, Joshua, Schmidt, Emily, Zhang, Zhaoyue, TeSlaa, Tara, Patel, Harshel, Chen, Li, Britt, Emily C., Piqueras-Nebot, Marta, Gomez-Cabrera, Mari Carmen, Lahoz, Agustín, Fan, Jing, Beier, Ulf H, Kim, Hahn, Rabinowitz, Joshua D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311271/
https://www.ncbi.nlm.nih.gov/pubmed/32393898
http://dx.doi.org/10.1038/s41589-020-0533-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311271/
https://www.ncbi.nlm.nih.gov/pubmed/32393898
http://dx.doi.org/10.1038/s41589-020-0533-x

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