Cargando…

A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway

Glucose is catabolized by two fundamental pathways, glycolysis to make ATP and the oxidative pentose phosphate pathway to make NADPH. The first step of the oxidative pentose phosphate pathway is catalyzed by the enzyme glucose-6-phosphate dehydrogenase (G6PD). Here we develop metabolite reporter and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ghergurovich, Jonathan M., García-Cañaveras, Juan C., Wang, Joshua, Schmidt, Emily, Zhang, Zhaoyue, TeSlaa, Tara, Patel, Harshel, Chen, Li, Britt, Emily C., Piqueras-Nebot, Marta, Gomez-Cabrera, Mari Carmen, Lahoz, Agustín, Fan, Jing, Beier, Ulf H, Kim, Hahn, Rabinowitz, Joshua D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311271/ https://www.ncbi.nlm.nih.gov/pubmed/32393898 http://dx.doi.org/10.1038/s41589-020-0533-x

Ejemplares similares

Serine catabolism generates liver NADPH and supports hepatic lipogenesis
por: Zhang, Zhaoyue, et al.
Publicado: (2021)

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
por: Stincone, Anna, et al.
Publicado: (2014)

Switching to the cyclic pentose phosphate pathway powers the oxidative burst in activated neutrophils
por: Britt, Emily C., et al.
Publicado: (2022)

Regulation of the pentose phosphate pathway in cancer
por: Jiang, Peng, et al.
Publicado: (2014)

The Entner-Doudoroff and Nonoxidative Pentose Phosphate Pathways Bypass Glycolysis and the Oxidative Pentose Phosphate Pathway in Ralstonia solanacearum
por: Jyoti, Poonam, et al.
Publicado: (2020)

Acidic Methanol Treatment Facilitates Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry Imaging of Energy Metabolism
por: Lu, Wenyun, et al.
Publicado: (2023)

SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia
por: García-Cañaveras, Juan C., et al.
Publicado: (2020)

The Pentose Phosphate Pathway Regulates the Circadian Clock
por: Rey, Guillaume, et al.
Publicado: (2016)

The Role of the Pentose Phosphate Pathway in Diabetes and Cancer
por: Ge, Tongxin, et al.
Publicado: (2020)

Queueing theory model of pentose phosphate pathway
por: Kloska, Sylwester M., et al.
Publicado: (2022)

Pentose Phosphate Pathway Reactions in Photosynthesizing Cells
por: Sharkey, Thomas D.
Publicado: (2021)

Tumor Microenvironment-Derived Metabolites: A Guide to Find New Metabolic Therapeutic Targets and Biomarkers
por: García-Cañaveras, Juan C., et al.
Publicado: (2021)

Avian influenza virus prevalence in marine birds is dependent on ocean temperatures
por: Hall, Jeffrey S., et al.
Publicado: (2019)

Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma
por: Kowalik, Marta Anna, et al.
Publicado: (2017)

The Pentose Phosphate Pathway and Its Involvement in Cisplatin Resistance
por: Giacomini, Isabella, et al.
Publicado: (2020)

Progressive obesity leads to altered ovarian gene expression in the Lethal Yellow mouse: a microarray study
por: Brannian, John, et al.
Publicado: (2009)

Experimental Infection of a North American Raptor, American Kestrel (Falco sparverius), with Highly Pathogenic Avian Influenza Virus (H5N1)
por: Hall, Jeffrey S., et al.
Publicado: (2009)

Evolution of a reassortant North American gull influenza virus lineage: drift, shift and stability
por: Hall, Jeffrey S, et al.
Publicado: (2013)

The Pentose Phosphate Pathway as a Potential Target for Cancer Therapy
por: Cho, Eunae Sandra, et al.
Publicado: (2018)

Expression of Pentose Phosphate Pathway-Related Proteins in Breast Cancer
por: Choi, Junjeong, et al.
Publicado: (2018)

Bypassing the Pentose Phosphate Pathway: Towards Modular Utilization of Xylose
por: Chomvong, Kulika, et al.
Publicado: (2016)

The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration
por: Tu, Dezhen, et al.
Publicado: (2019)

Two high-rate pentose-phosphate pathways in cancer cells
por: Cossu, Vanessa, et al.
Publicado: (2020)

Elevated pentose phosphate pathway flux supports appendage regeneration
por: Patel, Jeet H., et al.
Publicado: (2022)

Impact of the pentose phosphate pathway on metabolism and pathogenesis of Staphylococcus aureus
por: Kim, Jisun, et al.
Publicado: (2023)

Multiple Independent Fusions of Glucose-6-Phosphate Dehydrogenase with Enzymes in the Pentose Phosphate Pathway
por: Stover, Nicholas A., et al.
Publicado: (2011)

Increased expression of the oxidative pentose phosphate pathway and gluconeogenesis in anaerobically growing xylose-utilizing Saccharomyces cerevisiae
por: Runquist, David, et al.
Publicado: (2009)

Experimental challenge and pathology of highly pathogenic avian influenza virus H5N1 in dunlin (Calidris alpina), an intercontinental migrant shorebird species
por: Hall, Jeffrey S., et al.
Publicado: (2011)

Avian influenza in shorebirds: experimental infection of ruddy turnstones (Arenaria interpres) with avian influenza virus
por: Hall, Jeffrey S., et al.
Publicado: (2012)

Astroglial pentose phosphate pathway rates in response to high-glucose environments
por: Takahashi, Shinichi, et al.
Publicado: (2012)

TAp73 enhances the pentose phosphate pathway and supports cell proliferation
por: Du, Wenjing, et al.
Publicado: (2013)

Handling Uncertainty in Dynamic Models: The Pentose Phosphate Pathway in Trypanosoma brucei
por: Kerkhoven, Eduard J., et al.
Publicado: (2013)

Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway
por: Peiró, Concepción, et al.
Publicado: (2016)

Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma
por: Ahmad, F, et al.
Publicado: (2016)

Improvement of neuronal differentiation by carbon monoxide: Role of pentose phosphate pathway
por: Almeida, Ana S., et al.
Publicado: (2018)

Elevated pentose phosphate pathway is involved in the recovery of hypoxia-induced erythrocytosis
por: Liu, Chang, et al.
Publicado: (2017)

The plastidial pentose phosphate pathway is essential for postglobular embryo development in Arabidopsis
por: Andriotis, Vasilios M. E., et al.
Publicado: (2019)

6-Phosphogluconolactonase Promotes Hepatocellular Carcinogenesis by Activating Pentose Phosphate Pathway
por: Li, Changzheng, et al.
Publicado: (2021)

Targeting the Pentose Phosphate Pathway for SARS-CoV-2 Therapy
por: Bojkova, Denisa, et al.
Publicado: (2021)

The pentose phosphate pathway in industrially relevant fungi: crucial insights for bioprocessing
por: Masi, Audrey, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vbd10b65iu7b5o60tufkhamvl0