Lung IFNAR1(hi) TNFR2(+) cDC2 promotes lung regulatory T cells induction and maintains lung mucosal tolerance at steady state

The lung is a naturally tolerogenic organ. Lung regulatory T cells (T-regs) control lung mucosal tolerance. Here, we identified a lung IFNAR1(hi)TNFR2(+) conventional DC2 (iR2D2) population that induces T-regs in the lung at steady state. Using conditional knockout mice, adoptive cell transfer, rece...

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Detalles Bibliográficos
Autores principales: Mansouri, Samira, Katikaneni, Divya S., Gogoi, Himanshu, Pipkin, Mauricio, Machuca, Tiago N., Emtiazjoo, Amir M., Jin, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311323/
https://www.ncbi.nlm.nih.gov/pubmed/31959883
http://dx.doi.org/10.1038/s41385-020-0254-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311323/
https://www.ncbi.nlm.nih.gov/pubmed/31959883
http://dx.doi.org/10.1038/s41385-020-0254-1

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