Ultra-large chemical libraries for the discovery of high-affinity peptide binders

High-diversity genetically-encoded combinatorial libraries (10(8)−10(13) members) are a rich source of peptide-based binding molecules, identified by affinity selection. Synthetic libraries can access broader chemical space, but typically examine only ~ 10(6) compounds by screening. Here we show tha...

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Detalles Bibliográficos
Autores principales: Quartararo, Anthony J., Gates, Zachary P., Somsen, Bente A., Hartrampf, Nina, Ye, Xiyun, Shimada, Arisa, Kajihara, Yasuhiro, Ottmann, Christian, Pentelute, Bradley L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311396/
https://www.ncbi.nlm.nih.gov/pubmed/32576815
http://dx.doi.org/10.1038/s41467-020-16920-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311396/
https://www.ncbi.nlm.nih.gov/pubmed/32576815
http://dx.doi.org/10.1038/s41467-020-16920-3

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