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Ultra-large chemical libraries for the discovery of high-affinity peptide binders
High-diversity genetically-encoded combinatorial libraries (10(8)−10(13) members) are a rich source of peptide-based binding molecules, identified by affinity selection. Synthetic libraries can access broader chemical space, but typically examine only ~ 10(6) compounds by screening. Here we show tha...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311396/ https://www.ncbi.nlm.nih.gov/pubmed/32576815 http://dx.doi.org/10.1038/s41467-020-16920-3 |