Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis

SAMHD1 regulates cellular 2′-deoxynucleoside-5′-triphosphate (dNTP) homeostasis by catalysing the hydrolysis of dNTPs into 2′-deoxynucleosides and triphosphate. In CD4(+) myeloid lineage and resting T-cells, SAMHD1 blocks HIV-1 and other viral infections by depletion of the dNTP pool to a level that...

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Detalles Bibliográficos
Autores principales: Morris, Elizabeth R., Caswell, Sarah J., Kunzelmann, Simone, Arnold, Laurence H., Purkiss, Andrew G., Kelly, Geoff, Taylor, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311409/
https://www.ncbi.nlm.nih.gov/pubmed/32576829
http://dx.doi.org/10.1038/s41467-020-16983-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311409/
https://www.ncbi.nlm.nih.gov/pubmed/32576829
http://dx.doi.org/10.1038/s41467-020-16983-2

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