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Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis

SAMHD1 regulates cellular 2′-deoxynucleoside-5′-triphosphate (dNTP) homeostasis by catalysing the hydrolysis of dNTPs into 2′-deoxynucleosides and triphosphate. In CD4(+) myeloid lineage and resting T-cells, SAMHD1 blocks HIV-1 and other viral infections by depletion of the dNTP pool to a level that...

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Detalles Bibliográficos
Autores principales:	Morris, Elizabeth R., Caswell, Sarah J., Kunzelmann, Simone, Arnold, Laurence H., Purkiss, Andrew G., Kelly, Geoff, Taylor, Ian A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311409/ https://www.ncbi.nlm.nih.gov/pubmed/32576829 http://dx.doi.org/10.1038/s41467-020-16983-2

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