An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria

Peptide antibiotics are an abundant and synthetically tractable source of molecular diversity, but they are often cationic and can be cytotoxic, nephrotoxic and/or ototoxic, which has limited their clinical development. Here we report structure-guided optimization of an amphipathic peptide, arenicin...

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Detalles Bibliográficos
Autores principales: Elliott, Alysha G., Huang, Johnny X., Neve, Søren, Zuegg, Johannes, Edwards, Ingrid A., Cain, Amy K., Boinett, Christine J., Barquist, Lars, Lundberg, Carina Vingsbo, Steen, Jason, Butler, Mark S., Mobli, Mehdi, Porter, Kaela M., Blaskovich, Mark A. T., Lociuro, Sergio, Strandh, Magnus, Cooper, Matthew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311426/
https://www.ncbi.nlm.nih.gov/pubmed/32576824
http://dx.doi.org/10.1038/s41467-020-16950-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311426/
https://www.ncbi.nlm.nih.gov/pubmed/32576824
http://dx.doi.org/10.1038/s41467-020-16950-x

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