Cargando…

An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria

Peptide antibiotics are an abundant and synthetically tractable source of molecular diversity, but they are often cationic and can be cytotoxic, nephrotoxic and/or ototoxic, which has limited their clinical development. Here we report structure-guided optimization of an amphipathic peptide, arenicin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elliott, Alysha G., Huang, Johnny X., Neve, Søren, Zuegg, Johannes, Edwards, Ingrid A., Cain, Amy K., Boinett, Christine J., Barquist, Lars, Lundberg, Carina Vingsbo, Steen, Jason, Butler, Mark S., Mobli, Mehdi, Porter, Kaela M., Blaskovich, Mark A. T., Lociuro, Sergio, Strandh, Magnus, Cooper, Matthew A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311426/ https://www.ncbi.nlm.nih.gov/pubmed/32576824 http://dx.doi.org/10.1038/s41467-020-16950-x

Ejemplares similares

Contribution of Amphipathicity and Hydrophobicity to the Antimicrobial Activity and Cytotoxicity of β-Hairpin Peptides
por: Edwards, Ingrid A., et al.
Publicado: (2016)

Platinum Cyclooctadiene Complexes with Activity against Gram‐positive Bacteria
por: Frei, Angelo, et al.
Publicado: (2021)

Metals to combat antimicrobial resistance
por: Frei, Angelo, et al.
Publicado: (2023)

Approaches to querying bacterial genomes with transposon-insertion sequencing
por: Barquist, Lars, et al.
Publicado: (2013)

Institutional profile: Community for Open Antimicrobial Drug Discovery – crowdsourcing new antibiotics and antifungals
por: Desselle, Mathilde R, et al.
Publicado: (2017)

Nontoxic Cobalt(III) Schiff Base Complexes with Broad‐Spectrum Antifungal Activity
por: Frei, Angelo, et al.
Publicado: (2020)

Amphipathic Peptide Antibiotics with Potent Activity against Multidrug-Resistant Pathogens
por: Shi, Jingru, et al.
Publicado: (2021)

Synthesis of vancomycin fluorescent probes that retain antimicrobial activity, identify Gram-positive bacteria, and detect Gram-negative outer membrane damage
por: Zhang, Bing, et al.
Publicado: (2023)

The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation
por: Ng, Chai Ann, et al.
Publicado: (2011)

Amino Alcohols as Potential Antibiotic and Antifungal Leads
por: Baker, Jennifer R., et al.
Publicado: (2022)

An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants
por: Phetsang, Wanida, et al.
Publicado: (2014)

Metronidazole-triazole conjugates: Activity against Clostridium difficile and parasites
por: Jarrad, Angie M., et al.
Publicado: (2015)

The secondary resistome of multidrug-resistant Klebsiella pneumoniae
por: Jana, Bimal, et al.
Publicado: (2017)

The Many Faces of Amphipathic Helices
por: Giménez-Andrés, Manuel, et al.
Publicado: (2018)

Elucidating the Lipid Binding Properties of Membrane-Active Peptides Using Cyclised Nanodiscs
por: Zhang, Alan H., et al.
Publicado: (2019)

Cryptic susceptibility to penicillin/β-lactamase inhibitor combinations in emerging multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages
por: Ba, Xiaoliang, et al.
Publicado: (2023)

Preparation and Characterization of an Amphipathic Magnetic Nanosphere
por: Ji, Yongsheng, et al.
Publicado: (2014)

Interaction of Terminal Oxidases with Amphipathic Molecules
por: Azarkina, Natalia V., et al.
Publicado: (2023)

High-Throughput Analysis of Gene Essentiality and Sporulation in Clostridium difficile
por: Dembek, Marcin, et al.
Publicado: (2015)

In vitro Antimicrobial Activity of Acne Drugs Against Skin-Associated Bacteria
por: Blaskovich, Mark A. T., et al.
Publicado: (2019)

Structure-Function Studies of Polymyxin B Lipononapeptides
por: Gallardo-Godoy, Alejandra, et al.
Publicado: (2019)

Facially Amphipathic Glycopolymers Inhibit Ice Recrystallization
por: Graham, Ben, et al.
Publicado: (2018)

Prediction of amphipathic helix—membrane interactions with Rosetta
por: Gulsevin, Alican, et al.
Publicado: (2021)

Asymmetric effects of amphipathic molecules on mechanosensitive channels
por: Bavi, Omid, et al.
Publicado: (2022)

Joining Chain–Expressing and–Nonexpressing B Cell Populations in the Mouse
por: Erlandsson, Lena, et al.
Publicado: (2001)

Effects of Single Amino Acid Substitution on the Biophysical Properties and Biological Activities of an Amphipathic α-Helical Antibacterial Peptide Against Gram-Negative Bacteria
por: Tan, Juanjuan, et al.
Publicado: (2014)

Design of Novel Amphipathic α-Helical Antimicrobial Peptides with No Toxicity as Therapeutics against the Antibiotic-Resistant Gram-Negative Bacterial Pathogen, Acinetobacter Baumannii
por: Mant, Colin T, et al.
Publicado: (2019)

Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection
por: De Oliveira, David M. P., et al.
Publicado: (2022)

The TraDIS toolkit: sequencing and analysis for dense transposon mutant libraries
por: Barquist, Lars, et al.
Publicado: (2016)

Delivery of Inorganic Polyphosphate into Cells Using Amphipathic Oligocarbonate Transporters
por: Fernandes-Cunha, Gabriella M., et al.
Publicado: (2018)

Cholesterol Binds the Amphipathic Helix of IFITM3 and Regulates Antiviral Activity
por: Rahman, Kazi, et al.
Publicado: (2022)

Defining multidrug resistance in Gram-negative bacilli
por: Kumar, V. Anil, et al.
Publicado: (2015)

Multidrug Resistant Gram-Negative Bacteria in Community-Acquired Pneumonia
por: Cillóniz, C., et al.
Publicado: (2018)

Small amphipathic peptides are responsible for the assembly of cruciferin nanoparticles
por: Hong, Hui, et al.
Publicado: (2017)

Coemergence of the Amphipathic Helix on Ameloblastin With Mammalian Prismatic Enamel
por: Su, Jingtan, et al.
Publicado: (2022)

Membrane remodeling by the M2 amphipathic helix drives influenza virus membrane scission
por: Martyna, Agnieszka, et al.
Publicado: (2017)

Amphipathic Peptides Impede Lipid Domain Fusion in Phase-Separated Membranes
por: Pinigin, Konstantin V., et al.
Publicado: (2021)

Protein Amphipathic Helix Insertion: A Mechanism to Induce Membrane Fission
por: Zhukovsky, Mikhail A., et al.
Publicado: (2019)

Learning from Host-Defense Peptides: Cationic, Amphipathic Peptoids with Potent Anticancer Activity
por: Huang, Wei, et al.
Publicado: (2014)

Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats
por: Vingsbo-Lundberg, Carina, et al.
Publicado: (1998)

Cannot write session to /tmp/vufind_sessions/sess_ppm3lhml4tp8i5rr23loc01kim