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The iron–sulphur cluster in human DNA2 is required for all biochemical activities of DNA2

The nuclease/helicase DNA2 plays important roles in DNA replication, repair and processing of stalled replication forks. DNA2 contains an iron-sulphur (FeS) cluster, conserved in eukaryotes and in a related bacterial nuclease. FeS clusters in DNA maintenance proteins are required for structural inte...

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Detalles Bibliográficos
Autores principales: Mariotti, Laura, Wild, Sebastian, Brunoldi, Giulia, Piceni, Alessandra, Ceppi, Ilaria, Kummer, Sandra, Lutz, Richard E., Cejka, Petr, Gari, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311471/
https://www.ncbi.nlm.nih.gov/pubmed/32576938
http://dx.doi.org/10.1038/s42003-020-1048-4