Cargando…
Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation
Most eukaryotic genes produce alternative polyadenylation (APA) isoforms. Here we report that, unlike previously characterized cell lineages, differentiation of syncytiotrophoblast (SCT), a cell type critical for hormone production and secretion during pregnancy, elicits widespread transcript shorte...
Autores principales: | Cheng, Larry C., Zheng, Dinghai, Baljinnyam, Erdene, Sun, Fangzheng, Ogami, Koichi, Yeung, Percy Luk, Hoque, Mainul, Lu, Chi-Wei, Manley, James L., Tian, Bin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311474/ https://www.ncbi.nlm.nih.gov/pubmed/32576858 http://dx.doi.org/10.1038/s41467-020-16959-2 |
Ejemplares similares
-
Alternative cleavage and polyadenylation in spermatogenesis connects chromatin regulation with post-transcriptional control
por: Li, Wencheng, et al.
Publicado: (2016) -
Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster
por: Liu, Xiaochuan, et al.
Publicado: (2017) -
Comparative analysis of alternative polyadenylation in S. cerevisiae and S. pombe
por: Liu, Xiaochuan, et al.
Publicado: (2017) -
Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation
por: Li, Wencheng, et al.
Publicado: (2015) -
RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3′ UTRs
por: Di Giammartino, Dafne Campigli, et al.
Publicado: (2014)