Synergistic stabilization by nitrosoglutathione-induced thiol modifications in the stromal interaction molecule-2 luminal domain suppresses basal and store operated calcium entry

Stromal interaction molecule−1 and −2 (STIM1/2) are endoplasmic reticulum (ER) membrane-inserted calcium (Ca(2+)) sensing proteins that, together with Orai1-composed Ca(2+) channels on the plasma membrane (PM), regulate intracellular Ca(2+) levels. Recent evidence suggests that S-nitrosylation of th...

Descripción completa

Detalles Bibliográficos
Autores principales: Novello, Matthew J., Zhu, Jinhui, Zhang, MengQi, Feng, Qingping, Stathopulos, Peter B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311479/
https://www.ncbi.nlm.nih.gov/pubmed/32576932
http://dx.doi.org/10.1038/s41598-020-66961-3

Ejemplares similares

Ejemplares similares