Profound Nanoscale Structural and Biomechanical Changes in DNA Helix upon Treatment with Anthracycline Drugs

In our study, we describe the outcomes of the intercalation of different anthracycline antibiotics in double-stranded DNA at the nanoscale and single molecule level. Atomic force microscopy analysis revealed that intercalation results in significant elongation and thinning of dsDNA molecules. Additi...

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Detalles Bibliográficos
Autores principales: Kaczorowska, Aleksandra, Lamperska, Weronika, Frączkowska, Kaja, Masajada, Jan, Drobczyński, Sławomir, Sobas, Marta, Wróbel, Tomasz, Chybicka, Kinga, Tarkowski, Radosław, Kraszewski, Sebastian, Podbielska, Halina, Kałas, Wojciech, Kopaczyńska, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312087/
https://www.ncbi.nlm.nih.gov/pubmed/32531996
http://dx.doi.org/10.3390/ijms21114142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312087/
https://www.ncbi.nlm.nih.gov/pubmed/32531996
http://dx.doi.org/10.3390/ijms21114142

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