Enhanced Activity of P4503A4 and UGT1A10 Induced by Acridinone Derivatives C-1305 and C-1311 in MCF-7 and HCT116 Cancer Cells: Consequences for the Drugs’ Cytotoxicity, Metabolism and Cellular Response

Activity modulation of drug metabolism enzymes can change the biotransformation of chemotherapeutics and cellular responses induced by them. As a result, drug-drug interactions can be modified. Acridinone derivatives, represented here by C-1305 and C-1311, are potent anticancer drugs. Previous studi...

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Detalles Bibliográficos
Autores principales: Pawłowska, Monika, Kwaśniewska, Anna, Mazerska, Zofia, Augustin, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312182/
https://www.ncbi.nlm.nih.gov/pubmed/32486425
http://dx.doi.org/10.3390/ijms21113954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312182/
https://www.ncbi.nlm.nih.gov/pubmed/32486425
http://dx.doi.org/10.3390/ijms21113954

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