Improved efficacy, tolerance, safety, and abuse liability profile of the combination of CR4056 and morphine over morphine alone in rodent models

BACKGROUND AND PURPOSE: Prolonged use of opioids causes analgesic tolerance and adverse effects including constipation and dependence. Compounds targeting imidazoline I(2) receptors are known to potentiate opioid analgesia in rodents. We investigated whether combination with the I(2) receptor ligand...

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Detalles Bibliográficos
Autores principales: Sala, Emanuele, Ferrari, Flora, Lanza, Marco, Milia, Chiara, Sabatini, Chiara, Bonazzi, Albino, Comi, Eleonora, Borsi Franchini, Miriam, Caselli, Gianfranco, Rovati, Lucio Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312436/
https://www.ncbi.nlm.nih.gov/pubmed/32154915
http://dx.doi.org/10.1111/bph.15049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312436/
https://www.ncbi.nlm.nih.gov/pubmed/32154915
http://dx.doi.org/10.1111/bph.15049

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