New Tetrahydroacridine Hybrids with Dichlorobenzoic Acid Moiety Demonstrating Multifunctional Potential for the Treatment of Alzheimer’s Disease

A series of new tetrahydroacridine and 3,5-dichlorobenzoic acid hybrids with different spacers were designed, synthesized, and evaluated for their ability to inhibit both cholinesterase enzymes. Compounds 3a, 3b, 3f, and 3g exhibited selective butyrylcholinesterase (EqBuChE) inhibition with IC(50) v...

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Detalles Bibliográficos
Autores principales: Czarnecka, Kamila, Girek, Małgorzata, Wójtowicz, Przemysław, Kręcisz, Paweł, Skibiński, Robert, Jończyk, Jakub, Łątka, Kamil, Bajda, Marek, Walczak, Anna, Galita, Grzegorz, Kabziński, Jacek, Majsterek, Ireneusz, Szymczyk, Piotr, Szymański, Paweł
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312527/
https://www.ncbi.nlm.nih.gov/pubmed/32466601
http://dx.doi.org/10.3390/ijms21113765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312527/
https://www.ncbi.nlm.nih.gov/pubmed/32466601
http://dx.doi.org/10.3390/ijms21113765

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