Cargando…

New Tetrahydroacridine Hybrids with Dichlorobenzoic Acid Moiety Demonstrating Multifunctional Potential for the Treatment of Alzheimer’s Disease

A series of new tetrahydroacridine and 3,5-dichlorobenzoic acid hybrids with different spacers were designed, synthesized, and evaluated for their ability to inhibit both cholinesterase enzymes. Compounds 3a, 3b, 3f, and 3g exhibited selective butyrylcholinesterase (EqBuChE) inhibition with IC(50) v...

Descripción completa

Detalles Bibliográficos
Autores principales:	Czarnecka, Kamila, Girek, Małgorzata, Wójtowicz, Przemysław, Kręcisz, Paweł, Skibiński, Robert, Jończyk, Jakub, Łątka, Kamil, Bajda, Marek, Walczak, Anna, Galita, Grzegorz, Kabziński, Jacek, Majsterek, Ireneusz, Szymczyk, Piotr, Szymański, Paweł
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312527/ https://www.ncbi.nlm.nih.gov/pubmed/32466601 http://dx.doi.org/10.3390/ijms21113765

Ejemplares similares

New cyclopentaquinoline and 3,5-dichlorobenzoic acid hybrids with neuroprotection against oxidative stress for the treatment of Alzheimer’s disease
por: Czarnecka, Kamila, et al.
Publicado: (2023)

Discovery of New Cyclopentaquinoline Analogues as Multifunctional Agents for the Treatment of Alzheimer’s Disease
por: Czarnecka, Kamila, et al.
Publicado: (2019)

New cyclopentaquinoline hybrids with multifunctional capacities for the treatment of Alzheimer’s disease
por: Czarnecka, Kamila, et al.
Publicado: (2017)

Biological assessment of new tetrahydroacridine derivatives with fluorobenzoic moiety in vitro on A549 and HT-29 cell lines and in vivo on animal model
por: Kłosiński, Karol, et al.
Publicado: (2020)

Novel tetrahydroacridine derivatives with iodobenzoic moieties induce G0/G1 cell cycle arrest and apoptosis in A549 non-small lung cancer and HT-29 colorectal cancer cells
por: Girek, Małgorzata, et al.
Publicado: (2019)

Novel Cyclopentaquinoline and Acridine Analogs as Multifunctional, Potent Drug Candidates in Alzheimer’s Disease
por: Maciejewska, Karolina, et al.
Publicado: (2022)

Radiolabeled Peptides and Antibodies in Medicine
por: Kręcisz, Paweł, et al.
Publicado: (2020)

New Tacrine Analogs as Acetylcholinesterase Inhibitors — Theoretical Study with Chemometric Analysis
por: Szymański, Paweł, et al.
Publicado: (2013)

ASSOCIATION OF BASE EXCISION REPAIR PATHWAY GENES OGG1, XRCC1 AND MUTYH POLYMORPHISMS AND THE LEVEL OF 8-OXO-GUANINE WITH INCREASED RISK OF COLORECTAL CANCER OCCURRENCE
por: Kabziński, Jacek, et al.
Publicado: (2022)

The Role of the ER-Induced UPR Pathway and the Efficacy of Its Inhibitors and Inducers in the Inhibition of Tumor Progression
por: Walczak, Anna, et al.
Publicado: (2019)

Memantine in neurological disorders – schizophrenia and depression
por: Czarnecka, Kamila, et al.
Publicado: (2021)

MicroRNA as a Novel Biomarker in the Diagnosis of Head and Neck Cancer
por: Kabzinski, Jacek, et al.
Publicado: (2021)

RNA-Based Liquid Biopsy in Head and Neck Cancer
por: Kabzinski, Jacek, et al.
Publicado: (2023)

Sirt3 Regulates Response to Oxidative Stress by Interacting with BER Proteins in Colorectal Cancer
por: Kabzinski, J., et al.
Publicado: (2022)

Methyl 2,5-dichlorobenzoate
por: Babar, Tariq Mahmood, et al.
Publicado: (2008)

Cytotoxic Activity against A549 Human Lung Cancer Cells and ADMET Analysis of New Pyrazole Derivatives
por: Czylkowska, Agnieszka, et al.
Publicado: (2021)

Biological Evaluation, Molecular Docking, and SAR Studies of Novel 2-(2,4-Dihydroxyphenyl)-1H- Benzimidazole Analogues
por: Matysiak, Joanna, et al.
Publicado: (2019)

Association of Polymorphic Variants in Argonaute Genes with Depression Risk in a Polish Population
por: Kowalczyk, Mateusz, et al.
Publicado: (2022)

Inhibition of Protein Aggregation and Endoplasmic Reticulum Stress as a Targeted Therapy for α-Synucleinopathy
por: Siwecka, Natalia, et al.
Publicado: (2023)

Synthesis and Biological Studies of Novel Aminophosphonates and Their Metal Carbonyl Complexes (Fe, Ru)
por: Kosińska, Aneta, et al.
Publicado: (2022)

Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates
por: Lee, Hyun Myung, et al.
Publicado: (2021)

A review of the mechanisms underlying selected comorbidities in Alzheimer’s disease
por: Maciejewska, Karolina, et al.
Publicado: (2021)

Physico-Chemical Properties and Biocompatibility of Thermosensitive Chitosan Lactate and Chitosan Chloride Hydrogels Developed for Tissue Engineering Application
por: Pieklarz, Katarzyna, et al.
Publicado: (2021)

tert-Butylaminium 2-carboxy-4,5-dichlorobenzoate
por: Smith, Graham, et al.
Publicado: (2011)

Isopropylaminium 2-carboxy-4,5-dichlorobenzoate
por: Smith, Graham, et al.
Publicado: (2009)

4-Chloroanilinium 2-carboxy-4,5-dichlorobenzoate
por: Smith, Graham, et al.
Publicado: (2009)

The Cytotoxicity and Genotoxicity of Three Dental Universal Adhesives—An In Vitro Study
por: Wawrzynkiewicz, Adam, et al.
Publicado: (2020)

More Than Skin Deep – the Effects of Ultraviolet Radiation on Cathepsin K and Progerin Expression in Cultured Dermal Fibroblasts
por: Bednarski, Igor Aleksander, et al.
Publicado: (2021)

The Toxicity of Universal Dental Adhesives: An In Vitro Study
por: Wawrzynkiewicz, Adam, et al.
Publicado: (2021)

The Role of ER Stress-Related Phenomena in the Biology of Malignant Peripheral Nerve Sheath Tumors
por: Walczak, Anna, et al.
Publicado: (2021)

4-Methylpyridinium 2-carboxy-4,5-dichlorobenzoate monohydrate
por: Smith, Graham, et al.
Publicado: (2010)

Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase
por: Jończyk, Jakub, et al.
Publicado: (2021)

The Cytotoxicity and Genotoxicity of Bioactive Dental Materials
por: Kunert, Marta, et al.
Publicado: (2022)

Polymorphisms in DNA Repair Genes and Association with Rheumatoid Arthritis in a Pilot Study on a Central European Population
por: Galita, Grzegorz, et al.
Publicado: (2023)

1,10-Phenanthrolin-1-ium 2-carboxy-4,5-dichlorobenzoate
por: Smith, Graham, et al.
Publicado: (2009)

4-Methoxyanilinium 2-carboxy-4,5-dichlorobenzoate
por: Smith, Graham, et al.
Publicado: (2013)

2,4-Bis(arylethynyl)-9-chloro-5,6,7,8-tetrahydroacridines: synthesis and photophysical properties
por: Tka, Najeh, et al.
Publicado: (2021)

The Potential Role of Small-Molecule PERK Inhibitor LDN-0060609 in Primary Open-Angle Glaucoma Treatment
por: Rozpędek-Kamińska, Wioletta, et al.
Publicado: (2021)

Analysis of Binding Determinants for Different Classes of Competitive and Noncompetitive Inhibitors of Glycine Transporters
por: Łątka, Kamil, et al.
Publicado: (2022)

Analysis of Different Binding Modes for Tiagabine within the GAT-1 Transporter
por: Łątka, Kamil, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_06gqlgpr5j9e8r7i18ncjq3ova