Synthesis and Diels–Alder Reactivity of 4-Fluoro-4-Methyl-4H-Pyrazoles

4H-Pyrazoles are emerging scaffolds for “click” chemistry. Late-stage fluorination with Selectfluor(®) is found to provide a reliable route to 4-fluoro-4-methyl-4H-pyrazoles. 4-Fluoro-4-methyl-3,5-diphenyl-4H-pyrazole (MFP) manifested 7-fold lower Diels–Alder reactivity than did 4,4-difluoro-3,5-dip...

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Detalles Bibliográficos
Autores principales: Abularrage, Nile S., Levandowski, Brian J., Raines, Ronald T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312747/
https://www.ncbi.nlm.nih.gov/pubmed/32486503
http://dx.doi.org/10.3390/ijms21113964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312747/
https://www.ncbi.nlm.nih.gov/pubmed/32486503
http://dx.doi.org/10.3390/ijms21113964

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